URODYNAMIC EFFECTS OF BETA-ADRENOBLOCKERS: NEBIVOLOL ADVANTAGES

URODYNAMIC EFFECTS OF BETA-ADRENOBLOCKERS: NEBIVOLOL ADVANTAGES

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Aim.To compare urodynamic effects of beta-blockers with different selectivity (propranolol, metoprolol, nebivolol) in patients with arterial hypertension (HT) and concomitant benign prostatic hyperplasia (BPH).Material and methods.

32 patients (aged 67,5 y.o.in average) with HT of 1-2 stages were involved in the study.

All patients had BPH (prostate volume >40 sm3 , increase of residual urine volume) with moderate or severe NOCTURNA low urinary tract symptoms (IPSS 8-25) and reduction of maximum urine flow rate to 5-13 ml/s.The urodynamic effect of beta-blockers was estimated by changes of urination frequency and uroflowmetry indices after single taking and 14-day therapy.Results.

Propranolol and metoprolol led to aggravation of urination disorders.Nebivolol resulted in soft urodilating and urostimulating effects.It led ORG PINEAPPLE JUICE to urination improvement and reduced a risk of urodynamic disorders.

Conclusion.Urodynamic effects of cardiovascular drugs should be considered by practitioners especially in treatment of elderly patients.